Membroproliferative Glomerulonephropathy

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Introduction

Membroproliferative glomerulonephropathy is common in children and young adults, females moreso than males.

 

 

 

The Case of...

a simple case introducing clincial presentation and calling for a differential diagnosis to get students thinking.

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Causes and Risk Factors

Primary membranoproliferative GN can occur in two different patterns.

Type I is the more common, and is caused by subendothelial deposition by immune complexes. It can follow infection, tumours, drug reactions, genetic disorders, SLE, and complement deficiencies.

Type II is cause by activation of the alternative complement pathway following infection.

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Pathophysiology

Global basement membrane thickening and mesangial proliferation are seen.

 

In type I disease, immune complex deposition leads to inflammation and capillary thickening.

In type II disease, C3 complement deposition also leads to thickened capillaries. It is associated with partial lipodystrophy.

 

Basement membrane is rebuilt on top of areas of damage.

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Signs and Symptoms

  • history
  • physical exam

History

 

Physical Exam

 

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Investigations

  • lab investigations
  • diagnostic imaging

Lab Investigations

Membroproliferative GN can present with asymptomatic hematuria or combined nephritic/nephrotic syndrome.

Diagnostic Imaging

 

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Differential Diagnosis

 

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Treatments

Treatment includes dialysis and renal transplantation, but recurrence can also follow transplant, particularly in type II disease.

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Consequences and Course

Prognosis can be poor, with frequent progression to end-stage renal failure.

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Resources and References

 

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Topic Development

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